md.govHowever, both research studies, with professional or con results, concluded that Lysine is secure for most people, with some possible side effects of digestive upset (abdomen ache or diarrhea). There was one incident where a forty four year previous woman who had been taking 3000 mg of lysine per day for 5 years developed Franconi's syndrome, which manifested as tubulo-intersistial nephritis.

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