lawyer in my area consequence, prolonged use of OTC nasal sprays can lead to dependency, provides Dr. The exception to the rule is the DOT1 family, legal members of which methylate K79 within the globular area of histone H3 and which are structurally not related to SET-area proteins four - 6 Latest work means that SET-area-containing proteins methylate a few proteins in addition to histones (see later)